Most Common Vitamin Supplements

The Most Popular Vitamin Supplements in 2023

Discover the top supplements that can enhance your overall health and well-being. From vitamins to minerals, antioxidants to probiotics, this comprehensive guide will provide valuable insights into the world of supplementation and how it can support your body’s needs.

Vitamin D

Vitamin D, often referred to as the “sunshine vitamin,” offers a wide range of benefits for your health. Here are some key advantages of incorporating vitamin D into your daily routine:


Zinc is involved in various enzymatic reactions and acts as a cofactor for numerous enzymes, contributing to the metabolism of proteins, carbohydrates, and fats.


Turmeric has been used for centuries in Ayurvedic and traditional Chinese medicine


As an essential nutrient, it contributes to various bodily functions, including nerve cell health, DNA synthesis, and red blood cell production.

Vitamin D-3

The most commonly purchased supplement with many health benefits

By ensuring optimal vitamin D levels, you can support bone health, boost your immune system, enhance your mood, and reduce the risk of chronic diseases. Unlock the benefits of vitamin D and embrace a healthier, more vibrant life.

Vitamin D, also known as the “sunshine vitamin,” offers a range of benefits for overall health. It supports bone health, enhances immune function, improves mood, reduces the risk of chronic diseases, promotes muscle strength, and aids in pregnancy and child development. While sunlight is a natural source of vitamin D, supplementation is often necessary due to limited sun exposure. Consulting a healthcare professional is important to determine the appropriate dosage. By maintaining optimal vitamin D levels, individuals can support their well-being, from strong bones and a robust immune system to improved mood and protection against chronic diseases. Embrace the benefits of vitamin D for a healthier and more fulfilling life by incorporating this dietary supplement.

Scientific Evidence
Side Effects

Benefits and Side Effects

  1. Bone Health: Vitamin D plays a crucial role in calcium absorption, promoting strong bones and teeth. It helps regulate calcium and phosphorus levels in the body, which are essential for maintaining bone density and preventing conditions like osteoporosis and fractures.

  2. Immune Function: Vitamin D supports a healthy immune system, acting as a defense against infections and diseases. It helps stimulate the production and activity of immune cells, enhancing the body’s ability to fight off pathogens and reducing the risk of respiratory infections, such as the common cold and flu.

  3. Mood Regulation: Vitamin D has been linked to improved mood and mental well-being. Low levels of vitamin D have been associated with an increased risk of depression, seasonal affective disorder (SAD), and mood imbalances. Supplementing with vitamin D may help alleviate symptoms and improve overall mood.

  4. Chronic Disease Prevention: Research suggests that vitamin D may play a role in reducing the risk of chronic diseases. Studies have shown an association between higher vitamin D levels and a lower risk of conditions such as cardiovascular disease, type 2 diabetes, certain types of cancer (including colorectal, breast, and prostate), and autoimmune diseases like multiple sclerosis.

  5. Muscle Strength: Vitamin D supports muscle function and strength. It plays a role in muscle contraction and may help improve muscle performance, balance, and mobility. This is particularly important for older adults who are at a higher risk of muscle weakness and falls.

  6. Pregnancy and Child Development: Sufficient vitamin D levels during pregnancy are crucial for both the mother and the developing baby. Vitamin D supports proper fetal skeletal development and reduces the risk of complications like gestational diabetes and preeclampsia. It also plays a role in postpartum health and supports healthy breastfeeding.

Taking excessive amounts of vitamin D can lead to side effects. While vitamin D is generally considered safe when taken within recommended doses, consuming extremely high levels of vitamin D for prolonged periods can result in a condition called vitamin D toxicity or hypervitaminosis D.

Symptoms of vitamin D toxicity can include:

  1. Digestive Issues: Nausea, vomiting, and loss of appetite are common gastrointestinal symptoms associated with excessive vitamin D intake.

  2. Hypercalcemia: Vitamin D toxicity can cause an increase in blood calcium levels, leading to symptoms such as excessive thirst, frequent urination, kidney problems, constipation, and confusion.

  3. Kidney Damage: Prolonged excessive vitamin D intake can potentially damage the kidneys, impairing their function.

  4. Calcium Deposits: Excessive vitamin D can cause calcium to accumulate in soft tissues, leading to the formation of calcifications. This can affect various organs and tissues, including the heart, blood vessels, and kidneys.

It’s important to note that vitamin D toxicity is rare and typically occurs from very high supplemental doses, rather than from sun exposure or diet alone.

Scientific Evidence:

Scientific research has extensively investigated the role and benefits of vitamin D in human health. The evidence supports several key findings:

One important aspect is the impact of vitamin D on bone health. Studies consistently demonstrate that vitamin D deficiency increases the risk of bone diseases such as osteoporosis, fractures, and rickets. Adequate vitamin D levels are crucial for maintaining optimal bone density.

Vitamin D also plays a significant role in immune function. It helps regulate the activity of immune cells, which are essential for defending the body against pathogens. Research has shown that vitamin D deficiency is associated with a higher susceptibility to respiratory infections, autoimmune diseases, and chronic inflammation.

There is evidence suggesting a link between vitamin D and mood regulation. Low vitamin D levels have been correlated with an increased risk of depression and seasonal affective disorder (SAD). Some studies indicate that vitamin D supplementation may improve depressive symptoms, although further research is needed to fully understand this relationship.

Pricing: At about $8 per bottle, this is an extremely affordable supplement. We recommend this brand (NOW) because they are considered one of the top supplement companies in terms of quality of ingredients and accuracy of labeling. Several third party studies have validated the accuracy of the nutritional claims made by the company. 


An essential mineral, plays a crucial role in maintaining optimal health and well-being.

From immune system support and wound healing to cognitive function and hormonal balance, its importance cannot be overstated.

Zinc, an essential mineral, offers numerous benefits for overall health and well-being. Its advantages include immune system support, aiding in wound healing, enhancing cognitive function, promoting healthy skin, and contributing to hormonal balance. Zinc boosts immune function by producing immune cells, regulating inflammation, and supporting antibody development. It plays a crucial role in wound healing by promoting cell division, protein synthesis, and collagen formation. Zinc also supports cognitive function and neurological health, improves skin health by reducing inflammation and aiding in skin repair, and helps maintain hormonal balance. However, it is important to adhere to recommended daily intake levels and consult with a healthcare professional to avoid any potential side effects or interactions with medications.

Scientific Evidence
Side Effects

Benefits and Side Effects

  1. Immune System Support: Zinc is renowned for its immune-boosting properties. It helps strengthen the immune system by promoting the production of immune cells, regulating inflammation, and aiding in the development of antibodies. Adequate zinc intake can reduce the duration and severity of common infections such as the common cold and flu.

  2. Wound Healing: Zinc is essential for cell division, protein synthesis, and collagen formation, all of which are crucial for wound healing. It aids in tissue repair and can accelerate the recovery process for various injuries, including cuts, burns, and surgical wounds.

  3. Enhanced Cognitive Function: Research suggests that zinc plays a vital role in cognitive function and neurological health. It supports neurotransmitter regulation and helps maintain healthy brain function. Adequate zinc levels have been associated with improved memory, attention span, and overall cognitive performance.

  4. Skin Health: Zinc possesses anti-inflammatory and antioxidant properties, making it beneficial for various skin conditions. It can help alleviate acne, reduce skin inflammation, and support the healing of skin irritations. Additionally, zinc is a key component of many sunscreens, providing protection against harmful UV rays.

  5. Hormonal Balance: Zinc is involved in the production and regulation of hormones in the body. It contributes to the synthesis of testosterone in males and plays a role in maintaining hormonal balance in both men and women. Adequate zinc levels may support reproductive health, fertility, and overall hormonal function.

  1. Digestive Disturbances: Consuming excessive amounts of zinc can cause digestive issues such as nausea, vomiting, diarrhea, and abdominal cramps. These symptoms usually arise from high-dose zinc supplements or consuming zinc on an empty stomach. It is advisable to follow the recommended daily intake and take zinc with food to minimize digestive discomfort.

  2. Copper Imbalance: Zinc and copper maintain a delicate balance in the body. Excessive zinc intake can disrupt this equilibrium, leading to copper deficiency. Copper is essential for various bodily functions, including red blood cell production and connective tissue formation. Long-term zinc supplementation should be accompanied by copper intake to prevent any potential imbalance.

  3. Interactions with Medications: Certain medications, such as antibiotics and diuretics, can interfere with zinc absorption or increase its excretion. If you are taking any medications, it’s crucial to consult your healthcare provider before starting zinc supplements to avoid any potential interactions or reduced efficacy of the medications.

  4. Reduced Immune Function: While zinc is known to support immune function, excessively high levels can actually impair immune response. Prolonged, high-dose zinc supplementation may suppress the activity of certain immune cells, leading to decreased immune function. It is important to adhere to the recommended daily intake and avoid excessive zinc supplementation.

  5. Zinc Toxicity: Acute or chronic zinc toxicity is rare but can occur with extremely high doses of zinc supplements. Symptoms may include nausea, vomiting, headaches, and dizziness. Severe cases can lead to copper deficiency, altered iron function, and other metabolic imbalances

Scientific Evidence: Scientific evidence strongly supports the role of zinc as an essential mineral with various physiological functions. Numerous studies have highlighted its importance in immune system support, wound healing, cognitive function, skin health, and hormonal balance. Zinc has been shown to enhance immune response by increasing the production and activity of immune cells, reducing the severity and duration of common infections. Its involvement in wound healing is well-documented, as it promotes cell growth, protein synthesis, and collagen formation. Research also suggests that zinc plays a crucial role in cognitive function, memory, and attention span. Additionally, zinc’s anti-inflammatory and antioxidant properties contribute to skin health, alleviating conditions like acne and supporting wound healing. Its involvement in hormonal regulation, particularly in testosterone synthesis and overall hormonal balance, has been extensively studied. While scientific evidence showcases the benefits of zinc, it is important to consider individual needs, proper dosages, and potential interactions to maximize its positive effects. 

Pricing: At about $10 per bottle, this is an affordable supplement. We recommend this brand (NOW) because they are considered one of the top supplement companies in terms of quality of ingredients.


Curcumin, a naturally occurring compound found in turmeric

Curcumin is a bioactive compound found in the rhizomes of the turmeric plant (Curcuma longa). It is responsible for the vibrant yellow color of turmeric and has been used for centuries in Ayurvedic and traditional Chinese medicine

Curcumin has gained significant attention in recent years for its potential health benefits. This golden spice has been used for centuries in traditional medicine, and modern research has shed light on its diverse properties. While curcumin offers a wide range of potential advantages, it is crucial to be aware of its possible side effects. This article explores the benefits and side effects of curcumin to help you make informed decisions about incorporating it into your daily routine.

Scientific Evidence
Side Effects

Benefits and Side Effects

  1. Anti-Inflammatory Properties: Curcumin is renowned for its potent anti-inflammatory properties. It inhibits various molecules and enzymes involved in inflammation, potentially offering relief for individuals suffering from chronic inflammation-related conditions such as arthritis, inflammatory bowel disease, and certain cancers.

  2. Antioxidant Effects: Curcumin is a powerful antioxidant that helps neutralize harmful free radicals in the body. By protecting cells from oxidative stress, it may contribute to reducing the risk of chronic diseases like heart disease, diabetes, and neurodegenerative disorders.

  3. Potential Cancer-Fighting Properties: Numerous studies suggest that curcumin exhibits anticancer activities by interfering with cancer cell growth, promoting apoptosis (cell death), and inhibiting tumor formation. While more research is needed, curcumin shows promise in complementing conventional cancer treatments.

  4. Brain Health: Curcumin’s neuroprotective properties have attracted considerable interest. It crosses the blood-brain barrier and may help reduce the risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Curcumin’s potential to enhance brain function and mood is currently being investigated.

  5. Digestive Health: Curcumin has been traditionally used to support digestive health. It can help alleviate symptoms of indigestion, bloating, and gas. Furthermore, curcumin may protect against gastric ulcers and improve overall gut health.

  1. Digestive Issues: In some cases, high doses of curcumin may cause gastrointestinal discomfort, including diarrhea and nausea. Starting with small amounts and gradually increasing the dosage can help minimize these side effects.

  2. Interference with Medications: Curcumin may interact with certain medications, such as blood thinners (e.g., warfarin) and nonsteroidal anti-inflammatory drugs (NSAIDs). If you are taking any medications, it is advisable to consult your healthcare professional before incorporating curcumin supplements into your routine.

  3. Allergic Reactions: Although rare, some individuals may experience allergic reactions to curcumin or turmeric. If you notice symptoms such as hives, rash, or difficulty breathing, discontinue use and seek medical attention immediately.

  4. Low Bioavailability: Curcumin has low bioavailability, meaning that the body has difficulty absorbing it efficiently. To enhance absorption, it is often consumed with black pepper or combined with other substances that improve its bioavailability, such as piperine or liposomal formulations.

Scientific Evidence: Curcumin, the active compound in turmeric, has shown promising benefits in scientific research. It possesses anti-inflammatory and antioxidant properties, potentially offering relief for conditions linked to chronic inflammation. Curcumin also exhibits potential anticancer effects by inhibiting tumor growth and promoting cell death. Its neuroprotective properties suggest a role in reducing the risk of neurodegenerative diseases and enhancing brain function. Additionally, curcumin supports digestive health and may protect against gastric ulcers. However, it is important to be aware of potential side effects such as gastrointestinal discomfort. Further research is needed to fully understand the extent of curcumin’s benefits and limitations.

Pricing: At about $30 per bottle, this is a relatively affordable supplement. While there are some cheaper options, we recommend this brand. 


Vitamin B-12, also known as cobalamin, plays a crucial role in maintaining our overall health and well-being

As an essential nutrient, it contributes to various bodily functions, including nerve cell health, DNA synthesis, and red blood cell production. In this article, we will explore the benefits of vitamin B-12, potential side effects, and examine scientific research surrounding this vital nutrient.

vitamin B-12 plays a crucial role in supporting various bodily functions and promoting overall health. Its benefits encompass energy metabolism, nerve function, red blood cell production, cognitive health, and cardiovascular well-being. While it is generally safe, it is important to be mindful of potential side effects and consult a healthcare professional when necessary. By understanding the benefits, risks, and scientific research surrounding vitamin B-12, you can make informed decisions to optimize your health and well-being.

Scientific Evidence
Side Effects

Benefits and Side Effects

  1. Boosts Energy Levels: One of the primary benefits of vitamin B-12 is its ability to support energy metabolism. It helps convert food into usable energy, providing a natural and sustainable boost to your vitality.

  2. Enhances Nerve Function: Vitamin B-12 is essential for the maintenance of healthy nerve cells. It supports the formation of myelin, a protective coating that surrounds nerve fibers, facilitating efficient communication between the brain and the rest of the body.

  3. Supports Red Blood Cell Production: Adequate levels of vitamin B-12 are necessary for the production of red blood cells, which transport oxygen throughout the body. This nutrient ensures optimal oxygenation of tissues and organs, promoting overall vitality.

  4. Cognitive Function and Mental Health: Studies have suggested a link between vitamin B-12 and cognitive function. Adequate levels of B-12 may help maintain cognitive abilities and support healthy brain aging. Additionally, some research has explored the potential benefits of B-12 in managing mood disorders and reducing the risk of depression.

  5. Heart Health: Vitamin B-12 is involved in regulating homocysteine levels, an amino acid that, when elevated, is associated with an increased risk of cardiovascular disease. Adequate B-12 intake helps keep homocysteine levels in check, promoting a healthy heart.

  1. Allergic Reactions: In rare cases, individuals may experience allergic reactions, such as itching, swelling, or difficulty breathing, when taking vitamin B-12 supplements. If you experience any adverse reactions, it is advisable to seek medical attention immediately.

  2. Digestive Issues: High doses of vitamin B-12 may cause digestive discomfort, including nausea, diarrhea, or an upset stomach. These symptoms are generally mild and transient.

  3. Hypervitaminosis B-12: Prolonged and excessive intake of B-12 can lead to a condition known as hypervitaminosis B-12. This condition may result in acne-like skin reactions, frequent urination, or a sense of restlessness.

Scientific Evidence:

Extensive scientific research has been conducted to examine the effects of vitamin B-12 on various aspects of health. Some noteworthy studies include:

  1. Cognitive Decline and Dementia: Research has suggested that low levels of vitamin B-12 are associated with an increased risk of cognitive decline and dementia in older adults. Adequate B-12 intake through diet or supplementation may help support cognitive health.

  2. Depression and Mood Disorders: Several studies have explored the relationship between vitamin B-12 deficiency and mood disorders. While more research is needed, evidence suggests that maintaining sufficient B-12 levels may play a role in reducing the risk of depression and improving mood.

  3. Cardiovascular Health: Scientific investigations have linked low levels of vitamin B-12 to an increased risk of cardiovascular disease. Supplementation with B-12, along with other B-vitamins, may help lower homocysteine levels and reduce the risk of heart-related conditions.

Pricing: At about $12 per bottle, this is a relatively affordable supplement. While there are some cheaper options, we recommend this brand (NOW).

Incorporating dietary supplements, including popular choices such as vitamin D, zinc, turmeric, and B-12, can significantly enhance your overall health and well-being. These popular supplements are purchases so often due to their many benefits. Below provides more information about why we suggest incorprating them into your diet.

Vitamin D, a crucial dietary supplement, is essential for maintaining optimal bone and dental health. By facilitating the absorption of calcium and phosphorus, it fortifies bones, thereby reducing the risk of fractures and osteoporosis. Furthermore, vitamin D supports a robust immune system, helps regulate mood, and exhibits anti-inflammatory properties. For individuals with limited sun exposure or heightened deficiency risks, vitamin D supplementation can be particularly beneficial.

Another popular dietary supplement, zinc, plays a vital role in numerous bodily functions. It strengthens the immune system, supports wound healing, and contributes to proper growth and development. Zinc is also integral to cellular division, DNA synthesis, and hormone regulation. Supplementation with zinc is often recommended for individuals with deficient levels, compromised immune function, or specific health conditions.

Turmeric, renowned for its health benefits, is a favored dietary supplement due to its active compound curcumin. Curcumin possesses potent antioxidant and anti-inflammatory properties, making it effective in combating chronic inflammation and oxidative stress. This supplement has been associated with promoting joint health, improving cognitive function, enhancing cardiovascular well-being, and bolstering the immune response.

B-12, a key dietary supplement, is vital for red blood cell formation, neurological function, and DNA synthesis. Since it is primarily found in animal-based products, individuals adhering to vegan or vegetarian diets often require B-12 supplementation. Adequate B-12 intake can help prevent deficiency-related issues such as anemia, fatigue, and nerve damage.

It is important to remember that before commencing any new supplement regimen, it is advisable to consult with a healthcare professional. They can provide personalized guidance, determine appropriate dosages, and assess the suitability of these dietary supplements based on your specific health needs.

The history of minerals and vitamins is intertwined with the discovery and understanding of essential nutrients for human health. Throughout centuries, civilizations have recognized the importance of certain substances found in food that promote growth, vitality, and overall well-being. However, it was only in the late 19th and early 20th centuries that scientists began isolating and identifying these vital compounds. The advent of nutritional research led to the realization that specific minerals and vitamins played crucial roles in preventing diseases and supporting optimal bodily functions. As this knowledge expanded, so did the development of dietary supplements to address deficiencies and enhance nutritional intake. Today, supplement use has become increasingly prevalent, with individuals turning to these products to complement their diets and ensure they receive adequate amounts of essential minerals and vitamins for optimal health.

Howard E. Stanton, MD

Howard Stanton, M.D., is a practicing internist at Brigham and Women’s Hospital in Boston.

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