Managing Weight Gain from Psychiatric Medications

Psychiatric medications are important tools for treating mental health conditions such as depression, anxiety, and bipolar disorder. While these medications can be incredibly effective, they often come with a range of side effects, one of which is weight gain. Weight gain caused by psychiatric medications is a common concern for many patients. In fact, research suggests that weight gain is reported by up to 60% of patients taking some types of psychiatric medications.

The exact mechanism behind this weight gain is not fully understood. Some medications, such as atypical antipsychotics, are thought to directly increase appetite and disrupt metabolic processes. For others, weight gain may be related to changes in activity level or lifestyle factors such as poor diet. Whatever the cause, weight gain can be a significant concern for patients, as it can increase the risk of a range of health problems.

Understanding the Causes of Weight Gain from Psychiatric Medications

Psychiatric medications affect the way our bodies function in complex ways, and weight gain is just one of the many side effects they may have. Here are some of the ways that psychiatric medication can affect weight:

How psychiatric medications affect metabolism and appetite

Some medications used to treat mental health conditions have been shown to slow down the body's metabolism, which can make it harder to burn off calories. Other medications may impact the brain chemicals that regulate hunger and satiety, leading to an increase in appetite and overall food intake. These changes can cause weight gain even in people who don't change anything else about their usual diet or exercise habits.

The role of genetics

Research suggests that genetics may play a role in determining how likely someone is to gain weight from psychiatric medications. For example, some people may have a genetic predisposition to storing fat in certain areas of the body or to experiencing changes in appetite and metabolism when taking certain medications.

Lifestyle factors that contribute to weight gain

Certain lifestyle factors can also contribute to weight gain in people taking psychiatric medications. For example, someone who is already eating an unhealthy diet that is high in processed foods and sugar may be more likely to gain weight when taking medication that affects their appetite. Similarly, people who are already leading a sedentary lifestyle may be more likely to gain weight if they become less active because odf medication side effects or other factors. Stress can also play a role, as people who are experiencing high levels of stress may be more likely to engage in emotional eating or other behaviors that contribute to weight gain.

Strategies for Managing Weight Gain from Psychiatric Medications

Dietary considerations

One of the most effective ways to manage weight gain from psychiatric medications is by making dietary adjustments. Here are some tips:

  • Choose nutrient-dense foods: These are foods that are low in calories but high in nutrients. Examples include leafy greens, berries, lean proteins such as chicken and fish, and nuts and seeds.
  • Limit sugar and processed foods: These foods are often high in calories and low in nutrients, and can contribute to weight gain. Try to limit your intake of sugary drinks, candy, baked goods, and other heavily processed foods.
  • Incorporate whole grains, lean proteins, and healthy fats: These foods can help keep you feeling full and satisfied, which can reduce cravings. Examples include quinoa, brown rice, tofu, avocado, and olive oil.

Exercise considerations

Incorporating regular exercise into your routine can also be helpful for managing weight gain from psychiatric medications. Here are some things to keep in mind:

  • Choose the right type of physical activity: Not all types of exercise are created equal when it comes to weight management. High-intensity activities like running and weightlifting can be more effective for burning calories and building muscle than lower-intensity activities like walking or yoga.
  • Get enough exercise: Aim to get at least 30 minutes of moderate to vigorous physical activity most days of the week.
  • Find ways to make exercise enjoyable: If you don't enjoy the type of exercise you're doing, you're likely to give up on it. Try out different activities until you find something you enjoy, like dance classes, swimming, or hiking.

Medication changes

In some cases, adjusting your medication regimen may be necessary to manage weight gain. Here are some options:

  • Work with a healthcare provider to adjust doses: In some cases, reducing the dosage of your medication may help alleviate side effects like weight gain.
  • Switch medications: If weight gain is a major concern, your healthcare provider may recommend switching to a different medication that is less likely to cause weight gain.
  • Use additional medications for weight management: In some cases, medication specifically designed for weight management, such as orlistat or bupropion/naltrexone, may be prescribed in addition to your psychiatric medications.

By incorporating these strategies into a comprehensive weight management plan tailored to your individual needs, you can help manage weight gain related to psychiatric medications. Remember, it's important to work closely with your healthcare provider to find the right approach for you.

Mental Health Considerations

Managing weight gain from psychiatric medications can be challenging not only on a physical level but also on a mental and emotional level. Here are some mental health considerations to keep in mind:

Addressing underlying mental health concerns

It's important to remember that psychiatric medications are used to treat mental health conditions, which can themselves contribute to disordered eating patterns or negative body image. Addressing these underlying concerns may be an important aspect of addressing medication-induced weight gain. Some strategies for addressing underlying mental health concerns include:

  • Working with a mental health professional to address diagnosis and treatment of a mental health condition
  • Engaging in therapy or counseling to address negative body image or disordered eating patterns
  • Looking into support groups, which can provide a sense of community and reduce feelings of isolation

Addressing negative thoughts and emotions

Managing weight gain from psychiatric medications can also trigger negative thoughts and emotions. Some ways to address these feelings include:

  • Practicing self-compassion and avoiding negative self-talk
  • Engaging in mindfulness practices like meditation or deep breathing
  • Talking to a therapist or support group about your feelings

Developing healthy coping mechanisms

Finally, it can be helpful to develop healthy coping mechanisms for managing stress and anxiety that don't involve food or alcohol. Here are some ideas:

  • Engaging in regular exercise or physical activity
  • Trying out stress relief techniques like yoga or massage
  • Engaging in creative hobbies like painting or writing

Support for Managing Weight Gain from Psychiatric Medications

Managing weight gain from psychiatric medications can be a challenging and isolating experience. But know that you are not alone. There are many individuals and resources available to support you through this journey. Here are some support options you may find helpful:

Support Groups

Joining a support group can be an invaluable source of emotional support and community for individuals managing weight gain from psychiatric medications. These groups can offer a chance to connect with others who understand what you're going through and offer advice and encouragement. Support groups can be found online or in-person in many communities. Consider reaching out to mental health organizations or forums to locate support groups.

Family and Friends

Building a strong support network of family and friends can also be incredibly beneficial in managing weight gain. They can provide encouragement, accountability, and empathetic listening ears. Don't be afraid to share your struggles with your loved ones and ask for their support. It can also be helpful to involve family and friends in your healthy lifestyle changes by inviting them to join you in exercise or trying new healthy recipes together.

Healthcare Providers

Finally, healthcare providers are a crucial source of support when managing weight gain from psychiatric medications. Here are some healthcare providers that may be helpful:


Psychiatrists are medical doctors who specialize in treating mental health disorders, including those that may require psychiatric medications. They can help tailor your medication dosage or switch to medications with potentially less weight gain as a side effect. Additionally, they can provide support and counseling to address any underlying mental health conditions contributing to weight gain.


Nutritionists and dietitians are experts in food and nutrition. They can help you create meal plans that will support your physical and mental health, as well as help you manage your weight. They can also help you identify healthy snacks and alternatives to your favorite comfort foods.

Personal Trainers

Physical activity is an important part of managing weight gain from psychiatric medications. Personal trainers can help you develop an exercise routine that is safe and effective for your physical and emotional needs. They can demonstrate appropriate exercise form and provide motivation to help you stay on track.

Remember, managing weight gain from psychiatric medications is a journey. It's important to develop a team of people who can support you and provide you with the tools you need to succeed. With patience, self-kindness, and support, it's possible to thrive despite medication-induced weight gain.


Managing weight gain from psychiatric medications is a complex challenge that requires a comprehensive approach. However, the benefits of taking a proactive approach cannot be overstated. It's essential to prioritize your physical and mental health, and understand that weight gain is not a personal failure but rather, a common side effect of many psychiatric medications.

At times, it may feel like an uphill battle to attain and maintain a healthy weight, but do not be discouraged. Remember, even the smallest lifestyle changes can make a significant impact over time. Seek out support from loved ones and healthcare providers, and take small steps forward each day.

With patience, persistence, and a willingness to learn, it's possible to successfully manage weight gain from psychiatric medications. Healthier habits, a positive mindset, and a team of supportive advocates can help you lead a brighter, healthier, and happier life.

William H. McDaniel, MD

Dr. Robert H. Shmerling is the former clinical chief of the division of rheumatology at Beth Israel Deaconess Medical Center (BIDMC), and is a current member of the corresponding faculty in medicine at Harvard Medical School.

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