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How are Creatine Supplements Made? Inside the Factory

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Creatine is a popular supplement used by athletes and bodybuilders to improve performance and increase muscle mass. But have you ever wondered how creatine supplement is made? In this article, we will take you through the step-by-step process of creating creatine supplement.

Raw Materials

The first step in creating creatine supplement is to select the raw materials. Creatine is naturally found in the body and in certain foods such as meat and fish. However, the creatine used in supplements is typically made from synthetic sources. The raw materials used to create creatine supplement include sarcosine, cyanamide, and formaldehyde.


Once the raw materials have been selected, the synthesis process can begin. The first step in synthesis is to create methylamine. This is done by reacting sarcosine with formaldehyde. The resulting methylamine is then reacted with cyanamide to create creatine.


After synthesis, the creatine must be purified to remove any impurities. This is typically done using a process called chromatography. The creatine is dissolved in a solvent and then passed through a column containing a material that will selectively absorb impurities. The purified creatine is then dried and milled into a fine powder.

Mixing and Packaging

Once the creatine has been purified and dried, it is ready to be mixed with other ingredients and packaged. Creatine supplements are typically mixed with a carbohydrate such as dextrose or maltodextrin to improve absorption. The mixture is then packaged into capsules or powder form.

Quality Control

Throughout the process of creating creatine supplement, quality control measures are put in place to ensure that the final product is safe and effective. This includes testing the raw materials for purity, monitoring the synthesis process, and testing the final product for potency and purity.


Creating creatine supplement is a complex process that involves selecting the right raw materials, synthesizing creatine, purifying the final product, and ensuring quality control measures are in place. By understanding how creatine supplement is made, you can have a greater appreciation for this popular supplement and its benefits.

Caroline Buckee

Caroline Flannigan is an epidemiologist. She is an Associate Professor of Epidemiology and is the Associate Director of the Center for Communicable Disease Dynamics.

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