Does metabolism matter in weight loss?

Metabolism and Weight Loss

Have you ever heard someone complain about their slow metabolism, claiming they barely eat yet still gain weight? Or have you encountered someone who seems to eat whatever they want, including junk food, without gaining weight due to their fast metabolism? These situations raise important questions about the role of metabolism in weight gain and loss.

Metabolism, also known as metabolic rate, refers to the chemical reactions in a living organism that create and break down energy necessary for life. It's essentially the rate at which the body expends energy or burns calories. The body burns calories in several ways, including through the energy required to keep the body functioning at rest (basal metabolic rate), everyday activities, and exercise.

While genetics do play a role in metabolism, it's largely outside of an individual's control. Some people are fortunate enough to have inherited genes that promote a faster metabolism, allowing them to eat more without gaining weight. On the other hand, some people have a slower metabolism and require fewer calories to avoid becoming overweight.

One way to conceptualize metabolism is to think of the body as a car engine that's always running. Even when the body is at rest or sleeping, a certain amount of energy is burned just to keep the engine running. However, instead of gasoline, the fuel source is the calories from the food and beverages we consume. The speed of the body's "engine" over time determines the number of calories burned. A higher metabolism means more calories are burned at rest and during activity, requiring individuals to consume more calories to maintain their weight. Conversely, a lower metabolism burns fewer calories at rest and during activity, necessitating individuals to consume fewer calories to avoid becoming overweight.

While genetics play a role in determining metabolism, the environment also plays a role. It's important to note that weight gain or loss isn't solely determined by metabolism, but rather by a combination of factors including diet, exercise, and overall lifestyle.


Lean individuals tend to be more physically active during everyday tasks compared to overweight individuals. This is due to their tendency to fidget or move around even when not exercising. The cause of this difference in movement is unclear, but it can result in a significant difference in the number of calories burned daily.

Obese individuals may burn more calories than their lean counterparts during most activities, but they tend to be more sedentary, making it difficult to shed body fat. The cause of the rising obesity rates in the US cannot be solely attributed to an inherited slow metabolism. Environmental factors, such as a lack of exercise and changes in diet, are the more likely culprits.

Caloric Intake and Weight

Regardless of metabolism, excess weight is mainly caused by consuming more calories than what is burned through everyday activities. Our bodies are designed to store excess energy as fat cells, so consuming more calories than what is burned will result in weight gain. On the other hand, consuming fewer calories than what is burned will lead to weight loss. Losing weight can be challenging because our bodies sense a lack of food as starvation, which slows down our basal metabolic rate and reduces the number of calories burned over time.

Even small changes in calorie intake can result in significant weight gain or loss over time. The number of calories a person consumes, the feeling of fullness, and the tendency to eat beyond the point of fullness can all affect one's ultimate weight. Some believe that everyone has a set point weight at which their body is comfortable, and losing weight may lead to feeling hungry until reaching that set point weight.

In conclusion, while genetics and metabolism play a role in weight control, it is possible to change weight by balancing calorie intake with calorie burn from physical activity.

Caroline Buckee

Caroline Flannigan is an epidemiologist. She is an Associate Professor of Epidemiology and is the Associate Director of the Center for Communicable Disease Dynamics.

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